“I’m cool with your sexuality, but…”

My best friend did the same thing when I came out to her. I went for sort of between funny and serious, I guess. I leaned in really close to her face and whispered, "[friend], have I ever tried to make out with you before this?" And she answered no, and then I kissed her nose and said, "And I'm not about to start now just because you know I like chicks." (Though actually that could have gone really badly, so I'm not sure I'd recommend it as a strategy.)But if you think she was serious and it's causing problems, just explain to her that liking a gender doesn't mean you like everyone of the gender. Like, she probably likes guys, right? But I assume she doesn't kiss every guy she meets? It's basically the same thing. That might help her understand.

Did she say it with a smile? She may have been joking. I wouldn't think anything of it unless you see more signs that she is treating you like you're a romantic comedy away from confessing your love to her. Then you have a talk with her about it all.

Many people crack a joke or say something to be dismissive in order to break the tension they're feeling. I'd blow it off just as her being a good friend who got uncomfortable.

more often than not that is said because they are trying to be supportive but at the same time they really dont know what to say by the way hope im not being rude in saying so but i think the term your looking for is pansexual or omnisexual:

http://en.wikipedia.org/wiki/Pansexuality

Pansexuality, or omnisexuality,[1] is sexual attraction, sexual desire, romantic love, or emotional attraction toward people of all gender identities and biological sexes.[2][3] Self-identified pansexuals may consider pansexuality a sexual orientation,[3] and refer to themselves as gender-blind, asserting that gender and sex are insignificant or irrelevant in determining whether they will be sexually attracted to others.[4] The Oxford Dictionary of English defines pansexuality as, "not limited or inhibited in sexual choice with regard to gender or activity"

My class often has discussions on the gay football player, they'll often say 'I'm cool with gays, just as long as they don't make moves on me'. What most people don't get is that we still have standards. We wouldn't want to date our best friends if we were straight. They may be joking or not, I wouldn't sweat it too much, it gets said to people often.