I don't know your relationship, so I'm sorry if I sound like I'm pointing fingers. This is only from my experiences with a significant other being distant.
Is it possible you're not giving her enough space? To me it's a little crazy that a girl would want space, because I'm as clingy/lovey as can be, but all girls are different.
If it's an issue of space, maybe she's not getting enough time to herself or friends. It could be that she feels smothered, in a way.
If there is any possible way that she might be doing drugs, try to find out without really getting into her business, or being shady/sneaky.
Let her know how you feel. If you're feeling like you're not getting enough attention, tell her.
Let her know that she's been a little off lately, and that you're feeling like you're losing your bond. After telling her, take her out for dinner or a movie, a picnic. Let her know that you're concerned, and just want to help.