From experience with younger children, you'll probably want to wait until your new baby is at least a few months old. Take the time to heal from the delivery and make sure he/she is healthy. I can't think of anything worse than a crisis with your child if you're already in a difficult position from relocating.I'd strongly suggest against moving until at least one of you has secured a job in the new city. With the economy and unemployment rate still somewhat mangled, moving and THEN looking for work is a quick route to making your life substantially harder.If you're renting a home/apartment then you'll want to research the rough cost of living in your prospective new home and probably save enough for a couple months of rent + bills. That way you'll have move in fees and deposit and so forth taken care of, plus a buffer that can help sustain you while whichever partner didn't already have one finds a job.If it's close enough, or you can afford the trip, you might also want to make a weekend trip out to the spot you want to move to. Get a feel for whether it's really a place you want to live and take the chance to see what the prospective homes and the surrounding areas are really like. I've never in my life seen an apartment ad photo that looked remotely like the actual location.You didn't mention this specifically, but since a friend just did this: you may also want to consider how much of your desire to move is due to being unhappy and trying to physically get away from the problem.