I had a situation like that once, I was in a toxic friendship for years. Im very non-confrontational, so I couldn't get myself to tell her directly that I never wanted to speak to her again. Finally, I had enough after a very nasty comment she gave me . I summed up all my courage, because I really hate confrontation, with my heart beating so fast, and told her I had something to tell her. As soon as I started talking, I felt the biggest relief. It was over, I had said it, and there was no way that we could ever go back. It was a huge weight off my shoulders, and I am so glad that I finally confronted her about being a bad friend to me. You could also take the other route and start avoiding her more and more, and hope that she'll eventually get the message. It's up to you. And it depends how long you've been friends, and if she's mistreated you, or if you just aren't getting anything out of the friendship anymore. Either way, there is a big benefit to telling someone directly what's on your mind. It gets easier and easier the more you attempt to express yourself directly to others. Good luck!